ABSTRACT
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.
ABSTRACT
To estimate the levels of Dioxin and PCBs present in the plasma of women with different stages of endometriosis and relation between Dioxin, PCBs and their possible impact on the pathogenesis of endometriosis. A prospective case control study. Department of Reproductive Medicine, Bhagawan Mahavir Medical Research centre, Maternal Health and Research Trust, and Owaisi Hospital AND Research Center Hyderabad, Andhra Pradesh, India. 97 women with endometriosis undergoing laparoscopy and 102 controls. Heparinised blood samples were collected for dioxins, PCBs estimation. The levels of dioxins and PCBs were measured via gas chromatography. Women with endometriosis showed significantly higher concentrations of dioxin and PCBs when compared with the control group. The correlation between the concentrations of dioxin -TCDD, PCBs, and difference in the severity of endometriosis was strong and statistically significant at p<0.05 for all the four compounds PCB-1: r=+0.53; P<0.0001, PCB-5: r=+0.67; P<0.0001, PCB-29: r=+0.64; p<0.0001, PCB-98: r=+0.43; p<0.0014 and concentration of dioxin-TCDD: r=+0.36, p<0.0001. These results suggest that women having higher concentration of Dioxin and PCBs might have an increased susceptibility to endometriosis